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Sunday, December 21, 2014

Some of Sasha Shulgin's Work (Organic Chemistry Intro)

Sasha Shulgin invented over 200 different Medical Drugs that allowed us to learn all the things about Serotonin, and 5-HTP receptors that we know today, and a large portion of what he did was add "Methyl" groups to natural compounds. To methylate something, you put it in Methanol and when it attaches it adds a Methyl group.
Below is a representation where I tried to draw what a Glycine molecule might look like after it was Methylated. Methylation is just like making an Ester, but you specifically use Methanol as your Alcohol for the Ester. Methylation is another option that can be done to TONS of things, which will allow new smells to be made on and on, pretty much forever.
Acetic Acid can also be added to pretty much anything to create its Acetate form, I have not drawn any of those yet either. And Ethanol is also another specific Alcohol that makes Esters that have not been drawn here yet.
Adding an Acetoxy group is something else Sasha Shulgin did to Natural compounds. I do not understand it completely yet, but it seems as if you Oxidize something (Like how rust is made) this can be done with Hydrogen Peroxide and other Oxygen rich molecules. Then make the Acetal form after that.

Here are DMT and 5-MeO-DMT, they are probably the most well known example of a natural compound and its Methylated form. But both of them are natural compounds.,N-Dimethyltryptamine

4-AcO-DMT is the Acetoxy form of DMT.

Methanol has 1 Carbon, so it adds the "Methyl" group, but regular drinking Alcohol is known as "Ethanol" and it has 2 Carbons. So if you attach a drinking Alcohol molecule to something, it becomes its "Ethyl" form. Ethyl means it has 2 carbons.

Propane has 3 Carbons, and this makes the "Propyl" group, for example Isopropyl Alcohol/Rubbing Alcohol.



  1. methanol means 1 carbon and 1 oxygen with the remaining bonds filled by hydrogen. methanol is NOT the same as a methyl group, nor is ethanol the same as an ethyl group. and with 5-Meo-DMT and DMT, you would say that 5-Meo-DMT is a 5-methoxylated form of DMT. And "acetal" form generally means that you have turned a compound into a salt (a very genera term) using acetic acid (vinegar). It is fun to think about this stuff, but I recommend you head to and watch ALL of the chemistry and organic chemistry videos there before you post things that like this that are extremely inaccurate. MIT open courseware is another source, as well as youtube. You can find torrents for "math tutor dvds" on chemistry where you can solve problems using paper and a calculator. You just don't want people getting hurt and mixing ethyl alcohol with DMT thinking something is going to happen... not safe, bro.

    1. Thanks for the info, I learned from Sasha Shulgin's work not form a course.